Endocrine Abstracts

MEN1, autosomal dominant, is characterized by combined tumours of the parathyroid glands, pancreatic islet cells, and the anterior pituitary, sometimes associated with other endocrine (adrenocortical, foregut carcinoid) and nonendocrine (lipoma, angiofibroma, collagenoma, ependymoma, meningioma) tumors. It is caused by inactivating mutations of the MEN1 tumour suppressor gene (chromosome 11q13), encoding menin. Menin, involved in activation of gene transcription, regu...